Biotinylated Human LILRB3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human LILRB3/CD85a/ILT5 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001649)

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STJP001649
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Covered by St John's Laboratory Guarantee

Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LILRB3/CD85a/ILT5-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: LILRB3
Gene ID: 102725035/107987462
Uniprot ID: LIRB3_HUMAN
Immunogen Region: Gly24-Glu443
Immunogen: DNA sequence encoding Human LILRB3/CD85a/ILT5 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.
Function May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3
Lir-3
Leukocyte Immunoglobulin-Like Receptor 3
Cd85 Antigen-Like Family Member A
Immunoglobulin-Like Transcript 5
Ilt-5
Monocyte Inhibitory Receptor Hl9
Cd Antigen Cd85a
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 protein
Lir-3 protein
Leukocyte Immunoglobulin-Like Receptor 3 protein
Cd85 Antigen-Like Family Member A protein
Immunoglobulin-Like Transcript 5 protein
Ilt-5 protein
Monocyte Inhibitory Receptor Hl9 protein
Cd Antigen Cd85a protein
LILRB3 protein
ILT5 protein
LIR3 protein

Information sourced from Uniprot.org

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