Human LILRA4/ILT-7/CD85g protein (Recombinant) (C-His&Avi) (STJP020312)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human LILRA4/ILT-7/CD85g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu24-Asn446) of Human LILRA4/ILT-7/CD85g (Accession #) fused with His tag and Avi tag at the C-terminal.
General Information
| Short Description | Recombinant-Human LILRA4/ILT-7/CD85g-C-His&Avi protein was developed in hek293 cells using the region Glu24-Asn446. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | LILRA4 |
| Gene ID | 23547 |
| Uniprot ID | LIRA4_HUMAN |
| Immunogen | Recombinant Human LILRA4/ILT-7/CD85g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu24-Asn446) of Human LILRA4/ILT-7/CD85g (Accession #) fused with His tag and Avi tag at the C-terminal. |
| Immunogen Region | Glu24-Asn446 |
Additional Info
| Tissue Specificity | Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells. |
| Function | Functions coreceptor to limit the innate immune responses to viral infections.signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4Cd85 Antigen-Like Family Member GImmunoglobulin-Like Transcript 7Ilt-7Cd Antigen Cd85g |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 proteinCd85 Antigen-Like Family Member G proteinImmunoglobulin-Like Transcript 7 proteinIlt-7 proteinCd Antigen Cd85g proteinLILRA4 proteinILT7 protein |
Information sourced from Uniprot.org