Human LILRA3/ILT-6/CD85e protein (Recombinant) (C-His&Avi) {Biotin} (STJP020240)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human LILRA3/ILT-6/CD85e Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Glu439) of Human LILRA3/ILT-6/CD85e (Accession #) fused with His tag and Avi Tag at the C-te
General Information
| Short Description | Recombinant-Human LILRA3/ILT-6/CD85e-C-His&Avi protein was developed in hek293 cells using the region Gly24-Glu439. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | LILRA3 |
| Gene ID | 11026 |
| Uniprot ID | LIRA3_HUMAN |
| Immunogen | Biotinylated Recombinant Human LILRA3/ILT-6/CD85e Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Glu439) of Human LILRA3/ILT-6/CD85e (Accession #) fused with His tag and Avi Tag at the C-te |
| Immunogen Region | Gly24-Glu439 |
Additional Info
| Tissue Specificity | Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung. |
| Post Translational Modifications | N-glycosylation is required for ligand binding. |
| Function | Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3Cd85 Antigen-Like Family Member EImmunoglobulin-Like Transcript 6Ilt-6Leukocyte Immunoglobulin-Like Receptor 4Lir-4Monocyte Inhibitory Receptor Hm43/Hm31Cd Antigen Cd85e |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 proteinCd85 Antigen-Like Family Member E proteinImmunoglobulin-Like Transcript 6 proteinIlt-6 proteinLeukocyte Immunoglobulin-Like Receptor 4 proteinLir-4 proteinMonocyte Inhibitory Receptor Hm43/Hm31 proteinCd Antigen Cd85e proteinLILRA3 proteinILT6 proteinLIR4 protein |
Information sourced from Uniprot.org