| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human LILRA3/CD85e-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | LILRA3 |
| Gene ID: | 11026 |
| Uniprot ID: | LIRA3_HUMAN |
| Immunogen Region: | Gly24-Glu439 |
| Immunogen: | DNA sequence encoding Human LILRA3/CD85e including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Post Translational Modifications | N-glycosylation is required for ligand binding. |
| Function | Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 Cd85 Antigen-Like Family Member E Immunoglobulin-Like Transcript 6 Ilt-6 Leukocyte Immunoglobulin-Like Receptor 4 Lir-4 Monocyte Inhibitory Receptor Hm43/Hm31 Cd Antigen Cd85e |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 protein Cd85 Antigen-Like Family Member E protein Immunoglobulin-Like Transcript 6 protein Ilt-6 protein Leukocyte Immunoglobulin-Like Receptor 4 protein Lir-4 protein Monocyte Inhibitory Receptor Hm43/Hm31 protein Cd Antigen Cd85e protein LILRA3 protein ILT6 protein LIR4 protein |
Information sourced from Uniprot.org