Human LILRA2/CD85h protein (Recombinant) (C-His) (STJP001325)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human LILRA2/CD85h Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Asn449) of Human LILRA2 (Accession #NP_006857.2) fused with an 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human LILRA2/CD85h-C-His protein was developed in hek293 cells using the region Gly24-Asn449. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | LILRA2 |
| Gene ID | 11027 |
| Uniprot ID | LIRA2_HUMAN |
| Immunogen | Recombinant Human LILRA2/CD85h Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Asn449) of Human LILRA2 (Accession #NP_006857.2) fused with an 6×His tag at the C-terminus. |
| Immunogen Region | Gly24-Asn449 |
| Immunogen Sequence | GHLPKPTLWAEPGSVIIQGS PVTLRCQGSLQAEEYHLYRE NKSASWVRRIQEPGKNGQFP IPSITWEHAGRYHCQYYSHN HSSEYSDPLELVVTGAYSKP TLSALPSPVVTLGGNVTLQC VSQVAFDGFILCKEGEDEH PQRLNSHSHARGWSWAIFSV GPVSPSRRWSYRCYAYDSNS PYVWSLPSDLLELLVPGVSK KPSLSVQPGPMVAPGESLTL QCVSDVGYDRFVLYKEGERD |
Additional Info
| Function | Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2Cd85 Antigen-Like Family Member HImmunoglobulin-Like Transcript 1Ilt-1Leukocyte Immunoglobulin-Like Receptor 7Lir-7Cd Antigen Cd85h |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 proteinCd85 Antigen-Like Family Member H proteinImmunoglobulin-Like Transcript 1 proteinIlt-1 proteinLeukocyte Immunoglobulin-Like Receptor 7 proteinLir-7 proteinCd Antigen Cd85h proteinLILRA2 proteinILT1 proteinLIR7 protein |
Information sourced from Uniprot.org