• Human LILRA2/CD85h protein (Recombinant) (C-His) (STJP001325)

Human LILRA2/CD85h protein (Recombinant) (C-His) (STJP001325)

SKU:
STJP001325

£89.50 - £274.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: LILRA2
Gene ID: 11027
Uniprot ID: LIRA2_HUMAN
Immunogen: Recombinant Human LILRA2/CD85h Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Asn449) of Human LILRA2 (Accession #NP_006857.2) fused with an 6×His tag at the C-terminus.
Immunogen Sequence: GHLPKPTLWAEPGSVIIQGS PVTLRCQGSLQAEEYHLYRE NKSASWVRRIQEPGKNGQFP IPSITWEHAGRYHCQYYSHN HSSEYSDPLELVVTGAYSKP TLSALPSPVVTLGGNVTLQC VSQVAFDGFILCKEGEDEH PQRLNSHSHARGWSWAIFSV GPVSPSRRWSYRCYAYDSNS PYVWSLPSDLLELLVPGVSK KPSLSVQPGPMVAPGESLTL QCVSDVGYDRFVLYKEGERD
Function Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2
Cd85 Antigen-Like Family Member H
Immunoglobulin-Like Transcript 1
Ilt-1
Leukocyte Immunoglobulin-Like Receptor 7
Lir-7
Cd Antigen Cd85h
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 4: Secreted
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 protein
Cd85 Antigen-Like Family Member H protein
Immunoglobulin-Like Transcript 1 protein
Ilt-1 protein
Leukocyte Immunoglobulin-Like Receptor 7 protein
Lir-7 protein
Cd Antigen Cd85h protein
LILRA2 protein
ILT1 protein
LIR7 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance