| Function | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. |
| Protein Name | Galectin-8Gal-8Po66 Carbohydrate-Binding ProteinPo66-CbpProstate Carcinoma Tumor Antigen 1Pcta-1 |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmCytosol |
| Alternative Protein Names | Galectin-8 proteinGal-8 proteinPo66 Carbohydrate-Binding Protein proteinPo66-Cbp proteinProstate Carcinoma Tumor Antigen 1 proteinPcta-1 proteinLGALS8 protein |
Information sourced from Uniprot.org
