| Post Translational Modifications | Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin. |
| Function | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane. |
| Protein Name | Delta(14-Sterol Reductase LbrDelta-14-Sr3-Beta-Hydroxysterol Delta14-ReductaseC-14 Sterol ReductaseC14srIntegral Nuclear Envelope Inner Membrane ProteinLmn2rLamin-B ReceptorSterol C14-Reductase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2995383Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9022692 |
| Cellular Localisation | Nucleus Inner MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmNucleusNuclear Rim |
| Alternative Protein Names | Delta(14-Sterol Reductase Lbr proteinDelta-14-Sr protein3-Beta-Hydroxysterol Delta protein14-Reductase proteinC-14 Sterol Reductase proteinC14sr proteinIntegral Nuclear Envelope Inner Membrane Protein proteinLmn2r proteinLamin-B Receptor proteinSterol C14-Reductase proteinLBR protein |
Information sourced from Uniprot.org
