Human LBP protein (Recombinant-Active) (C-His) (STJP011899)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human LBP-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to enhance LPS stimulated IL-8 secretion by human acute monocytic leukemia cells (THP‑1). The ED50 for this effect is 0.25-2.5 ng/mL. |
Target Information
| Gene Symbol | LBP |
| Gene ID | 3929 |
| Uniprot ID | LBP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala26-Val481 |
Additional Info
| Function | Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. |
| Protein Name | Lipopolysaccharide-Binding ProteinLbp |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-166020Reactome: R-HSA-5686938Reactome: R-HSA-6785807 |
| Cellular Localisation | SecretedCytoplasmic Granule MembraneMembrane-Associated In Polymorphonuclear Leukocytes (Pmn) Granules |
| Alternative Protein Names | Lipopolysaccharide-Binding Protein proteinLbp proteinLBP protein |
Information sourced from Uniprot.org