| Post Translational Modifications | Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells.which induces the recruitment of GRB2. May be polyubiquitinated. |
| Function | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. |
| Protein Name | Linker For Activation Of T-Cells Family Member 2Linker For Activation Of B-CellsMembrane-Associated Adapter MoleculeNon-T-Cell Activation LinkerWilliams-Beuren Syndrome Chromosomal Region 15 ProteinWilliams-Beuren Syndrome Chromosomal Region 5 Protein |
| Database Links | Reactome: R-HSA-2730905 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative Protein Names | Linker For Activation Of T-Cells Family Member 2 proteinLinker For Activation Of B-Cells proteinMembrane-Associated Adapter Molecule proteinNon-T-Cell Activation Linker proteinWilliams-Beuren Syndrome Chromosomal Region 15 Protein proteinWilliams-Beuren Syndrome Chromosomal Region 5 Protein proteinLAT2 proteinLAB proteinNTAL proteinWBS15 proteinWBSCR15 proteinWBSCR5 proteinHSPC046 protein |
Information sourced from Uniprot.org
