Human LAMTOR4 protein (Recombinant) (N-His) (STJP016073)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LAMTOR4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | LAMTOR4 |
| Gene ID | 389541 |
| Uniprot ID | LTOR4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val99 |
Additional Info
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. |
| Protein Name | Ragulator Complex Protein Lamtor4Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Lysosome |
| Alternative Protein Names | Ragulator Complex Protein Lamtor4 proteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed proteinLAMTOR4 proteinC7orf59 protein |
Information sourced from Uniprot.org