| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human LAMP1 at 1 Mu g/mL (100 Mu L/well) can bind LAMP1 Rabbit pAb with a linear range of 1-8.5 ng/mL. |
| Gene Symbol: |
LAMP1 |
| Gene ID: |
3916 |
| Uniprot ID: |
LAMP1_HUMAN |
| Immunogen Region: |
Ala29-Met382 |
| Immunogen: |
Recombinant Human LAMP-1/CD107a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala29-Met382) of human LAMP1 (Accession #NP_005552.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
AMFMVKNGNGTACIMANFSA AFSVNYDTKSGPKNMTFDLP SDATVVLNRSSCGKENTSDP SLVIAFGRGHTLTLNFTRNA TRYSVQLMSFVYNLSDTHLF PNASSKEIKTVESITDIRAD IDKKYRCVSGTQVHMNNVTV TLHDATIQAYLSNSSFSRGE TRCEQDRPSPTTAPPAPPSP SPSPVPKSPSVDKYNVSGTN GTCLLASMGLQLNLTYERKD NTTVTRLLNINPNKTSASG |
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. (Microbial infection) Acts as a receptor for Lassa virus glycoprotein. Promotes also fusion of the virus with host membrane in less acidic endosomes. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. |
| Protein Name | Lysosome-Associated Membrane Glycoprotein 1Lamp-1Lysosome-Associated Membrane Protein 1Cd107 Antigen-Like Family Member ACd Antigen Cd107a |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneLate Endosome MembraneCell MembraneCytolytic Granule MembraneThis Protein Shuttles Between LysosomesEndosomesAnd The Plasma MembraneColocalizes With Osbpl1a At The Late Endosome |
| Alternative Protein Names | Lysosome-Associated Membrane Glycoprotein 1 proteinLamp-1 proteinLysosome-Associated Membrane Protein 1 proteinCd107 Antigen-Like Family Member A proteinCd Antigen Cd107a proteinLAMP1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
