• Human LAIR-1/CD305 protein (Recombinant) (C-His&Avi) (STJP001432)

Human LAIR-1/CD305 protein (Recombinant) (C-His&Avi) (STJP001432)

SKU:
STJP001432

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human LAIR-1/CD305-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: LAIR1
Gene ID: 3903
Uniprot ID: LAIR1_HUMAN
Immunogen: Recombinant Human LAIR-1/CD305 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-His163) of human LAIR1/CD305 (Accession #NP_068352.2) fused with a 6×His, Avi tag at the C-terminus.
Post Translational Modifications Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK. N-glycosylated.
Function Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Protein Name Leukocyte-Associated Immunoglobulin-Like Receptor 1
Lair-1
Hlair1
Cd Antigen Cd305
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte-Associated Immunoglobulin-Like Receptor 1 protein
Lair-1 protein
Hlair1 protein
Cd Antigen Cd305 protein
LAIR1 protein
CD305 protein

Information sourced from Uniprot.org

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