| Function | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. |
| Protein Name | N-Lysine Methyltransferase Kmt5aH4-K20-Hmtase Kmt5aHistone-Lysine N-Methyltransferase Kmt5aLysine N-Methyltransferase 5aLysine-Specific Methylase 5aPr/Set Domain-Containing Protein 07Pr-Set7Pr/Set07Set Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-2299718Reactome: R-HSA-3214841Reactome: R-HSA-6804760 |
| Cellular Localisation | NucleusChromosomeSpecifically Localizes To Mitotic ChromosomesColocalized With Sirt2 At Mitotic FociAssociates With Chromosomes During MitosisAssociation Is Increased In A H(2)O(2)-Induced Oxidative Stress-Dependent MannerAssociates With Silent Chromatin On Euchromatic ArmsNot Associated With Constitutive Heterochromatin |
| Alternative Protein Names | N-Lysine Methyltransferase Kmt5a proteinH4-K20-Hmtase Kmt5a proteinHistone-Lysine N-Methyltransferase Kmt5a proteinLysine N-Methyltransferase 5a proteinLysine-Specific Methylase 5a proteinPr/Set Domain-Containing Protein 07 proteinPr-Set7 proteinPr/Set07 proteinSet Domain-Containing Protein 8 proteinKMT5A proteinPRSET7 proteinSET07 proteinSET8 proteinSETD8 protein |
Information sourced from Uniprot.org
