| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human KMT2D-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | KMT2D |
| Gene ID: | 8085 |
| Uniprot ID: | KMT2D_HUMAN |
| Immunogen Region: | Val5381-Met5536 |
| Immunogen: | Homo sapiens (Human) |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. |
| Protein Name | Histone-Lysine N-Methyltransferase 2dLysine N-Methyltransferase 2dAll1-Related ProteinMyeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3214841Reactome: R-HSA-3769402Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Histone-Lysine N-Methyltransferase 2d proteinLysine N-Methyltransferase 2d proteinAll1-Related Protein proteinMyeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2 proteinKMT2D proteinALR proteinMLL2 proteinMLL4 protein |
Information sourced from Uniprot.org