Human KLRF1 protein (Recombinant) (N-His) (STJP013756)

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STJP013756-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KLRF1-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: KLRF1
Gene ID: 51348
Uniprot ID: KLRF1_HUMAN
Immunogen Region: Val66-Tyr231
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on Tyr-7.this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity.
Function Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases.
Protein Name Killer Cell Lectin-Like Receptor Subfamily F Member 1
Lectin-Like Receptor F1
Activating Coreceptor Nkp80
C-Type Lectin Domain Family 5 Member C
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Killer Cell Lectin-Like Receptor Subfamily F Member 1 protein
Lectin-Like Receptor F1 protein
Activating Coreceptor Nkp80 protein
C-Type Lectin Domain Family 5 Member C protein
KLRF1 protein
CLEC5C protein
ML protein

Information sourced from Uniprot.org

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