Human KLRF1 protein (Recombinant) (N-His) (STJP013756)

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STJP013756-100
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Short Description :Recombinant-Human KLRF1-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:KLRF1
Gene ID:51348
Uniprot ID:KLRF1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Val66-Tyr231
Post Translational Modifications Phosphorylated on Tyr-7.this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity.
Function Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases.
Protein Name Killer Cell Lectin-Like Receptor Subfamily F Member 1
Lectin-Like Receptor F1
Activating Coreceptor Nkp80
C-Type Lectin Domain Family 5 Member C
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Killer Cell Lectin-Like Receptor Subfamily F Member 1 protein
Lectin-Like Receptor F1 protein
Activating Coreceptor Nkp80 protein
C-Type Lectin Domain Family 5 Member C protein
KLRF1 protein
CLEC5C protein
ML protein

Information sourced from Uniprot.org

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