Human KISS1R protein (Recombinant) (N-His) (STJP005820)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KISS1R-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KISS1R |
| Gene ID | 84634 |
| Uniprot ID | KISSR_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile279-Leu398 |
Additional Info
| Function | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| Protein Name | Kiss-1 ReceptorKiss-1rG-Protein Coupled Receptor 54G-Protein Coupled Receptor Ot7t175Hot7t175Hypogonadotropin-1Kisspeptins ReceptorMetastin Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Kiss-1 Receptor proteinKiss-1r proteinG-Protein Coupled Receptor 54 proteinG-Protein Coupled Receptor Ot7t175 proteinHot7t175 proteinHypogonadotropin-1 proteinKisspeptins Receptor proteinMetastin Receptor proteinKISS1R proteinAXOR12 proteinGPR54 protein |
Information sourced from Uniprot.org