| Short Description : | Recombinant-Active-Human KIR3DS1/CD158e2-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to bind HLA on human breast cancer cells (MDA‑MB‑231). The ED50 for this effect is 0.03-0.18 Mu g/mL. |
| Gene Symbol: | KIR3DS1 |
| Gene ID: | 3813 |
| Uniprot ID: | KI3S1_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | His22-His340 |
| Function | Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 3ds1Natural Killer-Associated Transcript 10Nkat-10 |
| Database Links | Reactome: R-HSA-2172127 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Killer Cell Immunoglobulin-Like Receptor 3ds1 proteinNatural Killer-Associated Transcript 10 proteinNkat-10 proteinKIR3DS1 proteinNKAT10 protein |
Information sourced from Uniprot.org