Human Keratin 8/KRT8 protein (Recombinant) (His-Tag) (STJP018183)

Name: Human Keratin 8/KRT8 protein (Recombinant) (His-Tag) (STJP018183)
SKU: STJP018183
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018183

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Short Description	Recombinant-Human Keratin 8/KRT8-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	KRT8
Gene ID	3856
Uniprot ID	K2C8_HUMAN
Accession Number	NP_002264.1
Immunogen	Human
Immunogen Region	1-483aa
Immunogen Sequence	MSIRVTQ KSYKVSTSGP RAFSSRSYTS GPGSRISSSS FSRVGSSNFR GGLGGGYGGA SGMGGITAVT VNQSLLSPLV LEVDPNIQAV RTQEKEQIKT LNNKFASFID KVRFLEQQNK MLETKWSLLQ QQKTARSNMD NMFESYINNL RRQLETLGQE KLKLEAELGN MQGLVEDFKN KYEDEINKRT EMENEFVLIK KDVDEA

Tissue Specificity	Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Post Translational Modifications	Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Function	Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Protein Name	Keratin - Type Ii Cytoskeletal 8 Cytokeratin-8 Ck-8 Keratin-8 K8 Type-Ii Keratin Kb8
Database Links	Reactome: R-HSA-6805567 Reactome: R-HSA-6809371
Cellular Localisation	Cytoplasm Nucleus Nucleoplasm Nucleus Matrix
Alternative Protein Names	Keratin - Type Ii Cytoskeletal 8 protein Cytokeratin-8 protein Ck-8 protein Keratin-8 protein K8 protein Type-Ii Keratin Kb8 protein KRT8 protein CYK8 protein

Information sourced from Uniprot.org