| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4dJmjc Domain-Containing Histone Demethylation Protein 3dJumonji Domain-Containing Protein 2dHistone H3-Trimethyl-L-Lysine(9 Demethylase 4d |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Lysine-Specific Demethylase 4d proteinJmjc Domain-Containing Histone Demethylation Protein 3d proteinJumonji Domain-Containing Protein 2d proteinHistone H3-Trimethyl-L-Lysine(9 Demethylase 4d proteinKDM4D proteinJHDM3D proteinJMJD2D protein |
Information sourced from Uniprot.org