Human KCNH2/ERG1 protein (Recombinant) (N-His-SUMO) (STJP008881)

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STJP008881
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KCNH2/ERG1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KCNH2
Gene ID: 3757
Uniprot ID: KCNH2_HUMAN
Immunogen Region: Pro10-Lys135
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
Function Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. Isoform A-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Protein Name Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2
Eag Homolog
Ether-A-Go-Go-Related Gene Potassium Channel 1
Erg-1
Eag-Related Protein 1
Ether-A-Go-Go-Related Protein 1
H-Erg
Herg-1
Herg1
Potassium Voltage-Gated Channel Subfamily H Member 2
Voltage-Gated Potassium Channel Subunit Kv11.1
Database Links Reactome: R-HSA-1296072
Reactome: R-HSA-5576890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2 protein
Eag Homolog protein
Ether-A-Go-Go-Related Gene Potassium Channel 1 protein
Erg-1 protein
Eag-Related Protein 1 protein
Ether-A-Go-Go-Related Protein 1 protein
H-Erg protein
Herg-1 protein
Herg1 protein
Potassium Voltage-Gated Channel Subfamily H Member 2 protein
Voltage-Gated Potassium Channel Subunit Kv11.1 protein
KCNH2 protein
ERG protein
ERG1 protein
HERG protein

Information sourced from Uniprot.org

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