Human KCNAB2 protein (Recombinant) (N-His) (STJP015380)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KCNAB2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | KCNAB2 |
| Gene ID | 8514 |
| Uniprot ID | KCAB2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln37-Ser367 |
Additional Info
| Post Translational Modifications | Phosphorylated by PRKCZ.may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates. Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-2K(+ Channel Subunit Beta-2Kv-Beta-2Hkvbeta2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionAxonSynapseSynaptosomeCytoskeletonRecruited To The Cytoplasmic Side Of The Cell Membrane Via Its Interaction With Pore-Forming Potassium Channel Alpha SubunitsAssociates With Microtubules When Unphosphorylated |
| Alternative Protein Names | Voltage-Gated Potassium Channel Subunit Beta-2 proteinK(+ Channel Subunit Beta-2 proteinKv-Beta-2 proteinHkvbeta2 proteinKCNAB2 proteinKCNA2B proteinKCNK2 protein |
Information sourced from Uniprot.org