Human KATNA1 protein (Recombinant) (N-His) (STJP003355)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KATNA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KATNA1 |
| Gene ID | 11104 |
| Uniprot ID | KTNA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys167 |
Additional Info
| Function | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
| Protein Name | Katanin P60 Atpase-Containing Subunit A1Katanin P60 Subunit A1P60 Katanin |
| Database Links | |
| Cellular Localisation | CytoplasmMidbodyCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindlePredominantly CytoplasmicLocalized Diffusely In The Cytoplasm During The InterphaseDuring Metaphase Is Localized Throughout The Cell And More Widely Dispersed Than The MicrotubulesIn Anaphase And Telophase Is Localized At The Midbody RegionAlso Localized To The Interphase Centrosome And The Mitotic Spindle PolesEnhanced Recruitment To The Mitotic Spindle Poles Requires Microtubules And Interaction With Katnb1Localizes Within The CytoplasmPartially Overlapping With MicrotubulesIn Interphase And To The Mitotic Spindle And Spindle Poles During Mitosis |
| Alternative Protein Names | Katanin P60 Atpase-Containing Subunit A1 proteinKatanin P60 Subunit A1 proteinP60 Katanin proteinKATNA1 protein |
Information sourced from Uniprot.org