| Post Translational Modifications | Phosphorylated by casein kinase II upon estrogen stimulation. Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription. |
| Function | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation. |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2Ankyrin Repeat Domain-Containing Protein 25Matrix-Remodeling-Associated Protein 3Src-1-Interacting ProteinSipSrc-Interacting ProteinSrc1-Interacting Protein |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Protein Names | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2 proteinAnkyrin Repeat Domain-Containing Protein 25 proteinMatrix-Remodeling-Associated Protein 3 proteinSrc-1-Interacting Protein proteinSip proteinSrc-Interacting Protein proteinSrc1-Interacting Protein proteinKANK2 proteinANKRD25 proteinKIAA1518 proteinMXRA3 proteinSIP protein |
Information sourced from Uniprot.org
