Human Kallikrein-11 protein (Recombinant) (STJP000703)

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STJP000703
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Short Description :Recombinant-Human Kallikrein-11-protein was developed from hek293. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Formulation:Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction:Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity:The activity was tested by the ability to cleave a fluorogenic substrate VLK-SBzl.The specific activity was measured to be 300 pmole/ug/min NA
Gene Symbol:KLK11
Gene ID:11012
Uniprot ID:KLK11_HUMAN
Immunogen:Optimized DNA sequence encoding Human Kallikrein-11-hK11 (GLU19-ASN250) preprotein including a C-terminal His tag was expressed in HEK293 cells. NA
Immunogen Region:GLU19-ASN250
Tissue Specificity Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
Post Translational Modifications About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
Function Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Protein Name Kallikrein-11
Hk11
Hippostasin
Serine Protease 20
Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2
Database Links
Cellular Localisation Isoform 1: Secreted
Isoform 2: Golgi Apparatus
Secreted
Alternative Protein Names Kallikrein-11 protein
Hk11 protein
Hippostasin protein
Serine Protease 20 protein
Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 protein
KLK11 protein
PRSS20 protein
TLSP protein
UNQ649 protein
PRO1279 protein

Information sourced from Uniprot.org

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