| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human JAK1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | JAK1 |
| Gene ID: | 3716 |
| Uniprot ID: | JAK1_HUMAN |
| Immunogen Region: | Pro32-Phe286 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. Ubiquitinated by RNF125.leading to its degradation by the proteasome. |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
| Protein Name | Tyrosine-Protein Kinase Jak1Janus Kinase 1Jak-1 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-1169408Reactome: R-HSA-1266695Reactome: R-HSA-449836Reactome: R-HSA-5673001Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-6788467Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8854691Reactome: R-HSA-8983432Reactome: R-HSA-8984722Reactome: R-HSA-8985947Reactome: R-HSA-9020558Reactome: R-HSA-9020591Reactome: R-HSA-9020956Reactome: R-HSA-9020958Reactome: R-HSA-909733Reactome: R-HSA-912526Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9679191Reactome: R-HSA-9705462Reactome: R-HSA-9705671Reactome: R-HSA-9732724Reactome: R-HSA-9833109 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinWholly IntracellularPossibly Membrane Associated |
| Alternative Protein Names | Tyrosine-Protein Kinase Jak1 proteinJanus Kinase 1 proteinJak-1 proteinJAK1 proteinJAK1A proteinJAK1B protein |
Information sourced from Uniprot.org
