Human IZUMO1R protein (Recombinant) (C-His) (STJP010133)

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STJP010133
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IZUMO1R-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IZUMO1R
Gene ID: 390243
Uniprot ID: JUNO_HUMAN
Immunogen Region: Gly20-Ser228
Immunogen: Homo sapiens (Human)
Post Translational Modifications The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.
Function Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.
Protein Name Sperm-Egg Fusion Protein Juno
Folate Receptor 4
Folate Receptor Delta
Fr-Delta
Izumo1 Receptor Protein Juno
Database Links Reactome: R-HSA-163125
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Cell Projection
Microvillus Membrane
Gpi-Anchored At The Oolemma Microvilli
Alternative Protein Names Sperm-Egg Fusion Protein Juno protein
Folate Receptor 4 protein
Folate Receptor Delta protein
Fr-Delta protein
Izumo1 Receptor Protein Juno protein
IZUMO1R protein
FOLR4 protein
JUNO protein

Information sourced from Uniprot.org

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