Human IZUMO1 protein (Recombinant) (C-Strep) (STJP010145)

SKU:
STJP010145
£469.50 - £2,492.50
Free Shipping
Processing The item has been added

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IZUMO1-C-Strep protein was developed from mammalian cells and has a target region of C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IZUMO1
Gene ID: 284359
Uniprot ID: IZUM1_HUMAN
Immunogen Region: Cys22-Pro254
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm. Phosphorylated. The cytoplasmic C-terminus is phosphorylated and undergoes phosphorylation changes during epididymal transit.
Function Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization. FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion.
Protein Name Izumo Sperm-Egg Fusion Protein 1
Oocyte Binding/Fusion Factor
Obf
Sperm-Specific Protein Izumo
Database Links Reactome: R-HSA-1300645
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome Membrane
Localizes Initially To The Acrosome Membrane Of The Sperm Head (Both Outer And Inner Acrosomal Membranes)
During The Acrosome Reaction
Translocates To The Plasma Membrane
Alternative Protein Names Izumo Sperm-Egg Fusion Protein 1 protein
Oocyte Binding/Fusion Factor protein
Obf protein
Sperm-Specific Protein Izumo protein
IZUMO1 protein

Information sourced from Uniprot.org