| Short Description : | Recombinant-Human IYD-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact us for further information. |
| Gene Symbol: | IYD |
| Gene ID: | 389434 |
| Uniprot ID: | IYD1_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Tyr81-Val289 |
| Function | Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine. |
| Protein Name | Iodotyrosine Deiodinase 1Iyd-1Iodotyrosine Dehalogenase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic Vesicle Membrane |
| Alternative Protein Names | Iodotyrosine Deiodinase 1 proteinIyd-1 proteinIodotyrosine Dehalogenase 1 proteinIYD proteinC6orf71 proteinDEHAL1 protein |
Information sourced from Uniprot.org
