Human ITGa5 (Integrin Alpha 5) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016469)
SPECIFICATIONS
General Information
| Short Description | This ITGa5 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.054ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | ITGA5 |
| Gene ID | 3678 |
| Uniprot ID | ITA5_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in placenta (at protein level). |
| Post Translational Modifications | Proteolytic cleavage by PCSK5 mediates activation of the precursor. |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Protein Name | Integrin Alpha-5Cd49 Antigen-Like Family Member EFibronectin Receptor Subunit AlphaIntegrin Alpha-FVla-5Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-445144Reactome: R-HSA-8941332Reactome: R-HSA-9634597Reactome: R-HSA-9856532Reactome: R-HSA-9860927 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal Adhesion |
| Alternative ELISA Names | Integrin Alpha-5 ELISA kitCd49 Antigen-Like Family Member E ELISA kitFibronectin Receptor Subunit Alpha ELISA kitIntegrin Alpha-F ELISA kitVla-5 ELISA kitCd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain ELISA kitITGA5 ELISA kitFNRA ELISA kit |
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Information sourced from Uniprot.org