Human Intrinsic factor/CBLIF protein (Recombinant) (C-His) (STJP002453)
SPECIFICATIONS
HostHEK293 Cells
ConjugationUnconjugated
ImmunogenRecombinant Human Intrinsic factor/CBLIF Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Ser19-Tyr417) of human Intrinsic factor/CBLIF (Accession #NP_005133.2) fused with a 6×His tag at the C-term
General Information
| Short Description | Recombinant-Human Intrinsic factor/CBLIF-C-His protein was developed in hek293 cells using the region Ser19-Tyr417. For use in research applications. |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.01 EU/Mu g |
Target Information
| Gene Symbol | CBLIF |
| Gene ID | 2694 |
| Uniprot ID | IF_HUMAN |
| Immunogen | Recombinant Human Intrinsic factor/CBLIF Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Ser19-Tyr417) of human Intrinsic factor/CBLIF (Accession #NP_005133.2) fused with a 6×His tag at the C-term |
| Immunogen Region | Ser19-Tyr417 |
| Immunogen Sequence | STQTQSSCSVPSAQEPLVNG IQVLMENSVTSSAYPNPSIL IAMNLAGAYNLKAQKLLTYQ LMSSDNNDLTIGQLGLTIMA LTSSCRDPGDKVSILQRQME NWAPSSPNAEASAFYGPSLA ILALCQKNSEATLPIAVRFA KTLLANSSPFNVDTGAMATL ALTCMYNKIPVGSEEGYRSL FGQVLKDIVEKISMKIKDNG IIGDIYSTGLAMQALSVTPE PSKKEWNCKKTTDMILNEI |
Additional Info
| Function | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. |
| Protein Name | Cobalamin Binding Intrinsic FactorGastric Intrinsic FactorIntrinsic FactorIfInf |
| Database Links | Reactome: R-HSA-3359457Reactome: R-HSA-3359462Reactome: R-HSA-3359463Reactome: R-HSA-9758881 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Cobalamin Binding Intrinsic Factor proteinGastric Intrinsic Factor proteinIntrinsic Factor proteinIf proteinInf proteinCBLIF proteinGIF proteinIFMH protein |
Information sourced from Uniprot.org