| Short Description : | Recombinant-Human Integrin beta-6/ITGB6-C-His protein was developed in hek293 cells using the region Gly22-Asn707. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | ITGB6 |
| Gene ID: | 3694 |
| Uniprot ID: | ITB6_HUMAN |
| Immunogen: | Recombinant Human Integrin beta-6/ITGB6 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Gly22-Asn707) of human Integrin beta-6/ITGB6 (Accession #NP_000879.2) fused with 6×His tag at the C-terminus |
| Immunogen Region: | Gly22-Asn707 |
| Immunogen Sequence: | GCALGGAETCEDCLLIGPQC AWCAQENFTHPSGVGERCDT PANLLAKGCQLNFIENPVSQ VEILKNKPLSVGRQKNSSDI VQIAPQSLILKLRPGGAQTL QVHVRQTEDYPVDLYYLMDL SASMDDDLNTIKELGSRLSK EMSKLTSNFRLGFGSFVEKP VSPFVKTTPEEIANPCSSIP YFCLPTFGFKHILPLTNDAE RFNEIVKNQKISANIDTPEG GFDAIMQAAVCKEKIGWRN |
| Function | Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1. |
| Protein Name | Integrin Beta-6 |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2129379Reactome: R-HSA-216083Reactome: R-HSA-2173789Reactome: R-HSA-3000178 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal Adhesion |
| Alternative Protein Names | Integrin Beta-6 proteinITGB6 protein |
Information sourced from Uniprot.org
