Human Inhibin beta E/INHBE protein (Recombinant) (N-hFC) (STJP020380)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Inhibin beta E/INHBE Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr237-Ser350) of human Inhibin beta E/INHBE (Accession #NP_113667.1) fused with hFc tag at the N-terminus.
General Information
| Short Description | Recombinant-Human Inhibin beta E/INHBE-N-hFC protein was developed in hek293 cells using the region Thr237-Ser350. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | INHBE |
| Gene ID | 83729 |
| Uniprot ID | INHBE_HUMAN |
| Immunogen | Recombinant Human Inhibin beta E/INHBE Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr237-Ser350) of human Inhibin beta E/INHBE (Accession #NP_113667.1) fused with hFc tag at the N-terminus. |
| Immunogen Region | Thr237-Ser350 |
| Immunogen Sequence | TPTCEPATPLCCRRDHYVDF QELGWRDWILQPEGYQLNYC SGQCPPHLAGSPGIAASFHS AVFSLLKANNPWPASTSCCV PTARRPLSLLYLDHNGNVVK TDVPDMVVEACGCS |
Additional Info
| Function | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver. Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control. Induces beige adipocyte formation and thermogenesis in response to cold exposure. |
| Protein Name | Inhibin Beta E ChainActivin Beta-E Chain |
| Database Links | Reactome: R-HSA-209822 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Inhibin Beta E Chain proteinActivin Beta-E Chain proteinINHBE protein |
Information sourced from Uniprot.org