| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IL1RL1/ST2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL33 at 10 Mu g/mL (100 Mu L/well) can bind Recombinant Human ST2 with a linear range of 1.41-5.64 Mu g/mL. |
| Gene Symbol: |
IL1RL1 |
| Gene ID: |
9173 |
| Uniprot ID: |
ILRL1_HUMAN |
| Immunogen Region: |
Lys19-Phe328 |
| Immunogen: |
Recombinant Human IL1RL1/ST2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys19-Phe328) of human ST2 (Accession #NP_003847.2) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | Ubiquitinated at Lys-321 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Protein St2 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-6811558Reactome: R-HSA-9014843 Q01638-2 |
| Cellular Localisation | Isoform C: Cell MembraneIsoform B: SecretedCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-1 Receptor-Like 1 proteinProtein St2 proteinIL1RL1 proteinDER4 proteinST2 proteinT1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
