| Short Description : | Recombinant-Active-Human IL12RB2-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. When recombinant human IL‑12 is Immobilised at 0.5 Mu g/mL, 100 Mu L/well, the concentration of recombinant human IL12RB2 that produces 50% of the optimal binding response is 0.015-0.09 Mu g/mL. |
| Gene Symbol: | IL12RB2 |
| Gene ID: | 3595 |
| Uniprot ID: | I12R2_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Lys24-Asn622 |
| Post Translational Modifications | On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. |
| Function | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-2Il-12 Receptor Subunit Beta-2Il-12r Subunit Beta-2Il-12r-Beta-2Il-12rb2 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020591 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-12 Receptor Subunit Beta-2 proteinIl-12 Receptor Subunit Beta-2 proteinIl-12r Subunit Beta-2 proteinIl-12r-Beta-2 proteinIl-12rb2 proteinIL12RB2 protein |
Information sourced from Uniprot.org
