Human IL11RA protein (Recombinant-Active) (C-His) (STJP012109)

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STJP012109-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human IL11RA-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: IL11RA
Gene ID: 3590
Uniprot ID: I11RA_HUMAN
Immunogen Region: Ser24-Val363
Immunogen: Homo sapiens (Human)
Post Translational Modifications A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
Function Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. Isoform HCR2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
Protein Name Interleukin-11 Receptor Subunit Alpha
Il-11 Receptor Subunit Alpha
Il-11r Subunit Alpha
Il-11r-Alpha
Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha
Sil-11r
Sil-11ra
Sil11ra
Database Links Reactome: R-HSA-6788467
Cellular Localisation Interleukin-11 Receptor Subunit Alpha: Membrane
Single-Pass Type I Membrane Protein
Soluble Interleukin-11 Receptor Subunit Alpha: Secreted
Isoform Hcr2: Secreted
Alternative Protein Names Interleukin-11 Receptor Subunit Alpha protein
Il-11 Receptor Subunit Alpha protein
Il-11r Subunit Alpha protein
Il-11r-Alpha protein
Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha protein
Sil-11r protein
Sil-11ra protein
Sil11ra protein
IL11RA protein

Information sourced from Uniprot.org

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