| Post Translational Modifications | Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP.leading to impaired neutrophil endothelial transmigration and thus increased virulence. |
| Function | Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways. |
| Protein Name | Interleukin-8Il-8C-X-C Motif Chemokine 8ChemokineC-X-C Motif Ligand 8EmoctakinGranulocyte Chemotactic Protein 1Gcp-1Monocyte-Derived Neutrophil Chemotactic FactorMdncfMonocyte-Derived Neutrophil-Activating PeptideMonapNeutrophil-Activating Protein 1Nap-1Protein 3-10cT-Cell Chemotactic Factor Cleaved Into - Mdncf-AGcp/Il-8 Protein IvIl8/Nap1 Form I - Interleukin-8(Ala-Il-877Gcp/Il-8 Protein IiIl-8(1-77Il8/Nap1 Form IiMdncf-B - Il-8(5-77 - Il-8(6-77(Ser-Il-872Gcp/Il-8 Protein IIl8/Nap1 Form IiiLymphocyte-Derived Neutrophil-Activating FactorLynapMdncf-CNeutrophil-Activating FactorNaf - Il-8(7-77Gcp/Il-8 Protein VIl8/Nap1 Form Iv - Il-8(8-77Gcp/Il-8 Protein ViIl8/Nap1 Form V - Il-8(9-77Gcp/Il-8 Protein IiiIl8/Nap1 Form Vi |
| Database Links | Reactome: R-HSA-2559582Reactome: R-HSA-375276Reactome: R-HSA-380108Reactome: R-HSA-380994Reactome: R-HSA-418594Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-8 antibody pairIl-8 antibody pairC-X-C Motif Chemokine 8 antibody pairChemokine antibody pairC-X-C Motif Ligand 8 antibody pairEmoctakin antibody pairGranulocyte Chemotactic Protein 1 antibody pairGcp-1 antibody pairMonocyte-Derived Neutrophil Chemotactic Factor antibody pairMdncf antibody pairMonocyte-Derived Neutrophil-Activating Peptide antibody pairMonap antibody pairNeutrophil-Activating Protein 1 antibody pairNap-1 antibody pairProtein 3-10c antibody pairT-Cell Chemotactic Factor Cleaved Into - Mdncf-A antibody pairGcp/Il-8 Protein Iv antibody pairIl8/Nap1 Form I - Interleukin-8 antibody pair(Ala-Il-877 antibody pairGcp/Il-8 Protein Ii antibody pairIl-8(1-77 antibody pairIl8/Nap1 Form Ii antibody pairMdncf-B - Il-8(5-77 - Il-8(6-77 antibody pair(Ser-Il-872 antibody pairGcp/Il-8 Protein I antibody pairIl8/Nap1 Form Iii antibody pairLymphocyte-Derived Neutrophil-Activating Factor antibody pairLynap antibody pairMdncf-C antibody pairNeutrophil-Activating Factor antibody pairNaf - Il-8(7-77 antibody pairGcp/Il-8 Protein V antibody pairIl8/Nap1 Form Iv - Il-8(8-77 antibody pairGcp/Il-8 Protein Vi antibody pairIl8/Nap1 Form V - Il-8(9-77 antibody pairGcp/Il-8 Protein Iii antibody pairIl8/Nap1 Form Vi antibody pairCXCL8 antibody pairIL8 antibody pair |
Information sourced from Uniprot.org
