• Human IL-8/GCP-1/NAP-1 protein (Recombinant) (No tag) (STJP000827)
  • Human IL-8/GCP-1/NAP-1 protein (Recombinant) (No tag) (STJP000827)
  • Human IL-8/GCP-1/NAP-1 protein (Recombinant) (No tag) (STJP000827)
  • Human IL-8/GCP-1/NAP-1 protein (Recombinant) (No tag) (STJP000827)

Human IL-8/GCP-1/NAP-1 protein (Recombinant) (No tag) (STJP000827)

SKU:
STJP000827

£76.50 - £105.50
Current Stock:
Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-8/GCP-1/NAP-1-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its ability to enhance Bcl2 expression in HCT116 human colon adenocarcinoma cells.0.01-1ng/mL of Recombinant Human IL-8 can effectively enhance Bcl2 expression.
Gene Symbol: CXCL8
Gene ID: 3576
Uniprot ID: IL8_HUMAN
Immunogen: Recombinant Human IL-8/CXCL8/GCP-1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala23-Ser99) of human IL-8 (Accession #NP_000575.1).
Post Translational Modifications Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP.leading to impaired neutrophil endothelial transmigration and thus increased virulence.
Function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Protein Name Interleukin-8
Il-8
C-X-C Motif Chemokine 8
Chemokine
C-X-C Motif Ligand 8
Emoctakin
Granulocyte Chemotactic Protein 1
Gcp-1
Monocyte-Derived Neutrophil Chemotactic Factor
Mdncf
Monocyte-Derived Neutrophil-Activating Peptide
Monap
Neutrophil-Activating Protein 1
Nap-1
Protein 3-10c
T-Cell Chemotactic Factor Cleaved Into - Mdncf-A
Gcp/Il-8 Protein Iv
Il8/Nap1 Form I - Interleukin-8
(Ala-Il-877
Gcp/Il-8 Protein Ii
Il-8(1-77
Il8/Nap1 Form Ii
Mdncf-B - Il-8(5-77 - Il-8(6-77
(Ser-Il-872
Gcp/Il-8 Protein I
Il8/Nap1 Form Iii
Lymphocyte-Derived Neutrophil-Activating Factor
Lynap
Mdncf-C
Neutrophil-Activating Factor
Naf - Il-8(7-77
Gcp/Il-8 Protein V
Il8/Nap1 Form Iv - Il-8(8-77
Gcp/Il-8 Protein Vi
Il8/Nap1 Form V - Il-8(9-77
Gcp/Il-8 Protein Iii
Il8/Nap1 Form Vi
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-375276
Reactome: R-HSA-380108
Reactome: R-HSA-380994
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Alternative Protein Names Interleukin-8 protein
Il-8 protein
C-X-C Motif Chemokine 8 protein
Chemokine protein
C-X-C Motif Ligand 8 protein
Emoctakin protein
Granulocyte Chemotactic Protein 1 protein
Gcp-1 protein
Monocyte-Derived Neutrophil Chemotactic Factor protein
Mdncf protein
Monocyte-Derived Neutrophil-Activating Peptide protein
Monap protein
Neutrophil-Activating Protein 1 protein
Nap-1 protein
Protein 3-10c protein
T-Cell Chemotactic Factor Cleaved Into - Mdncf-A protein
Gcp/Il-8 Protein Iv protein
Il8/Nap1 Form I - Interleukin-8 protein
(Ala-Il-877 protein
Gcp/Il-8 Protein Ii protein
Il-8(1-77 protein
Il8/Nap1 Form Ii protein
Mdncf-B - Il-8(5-77 - Il-8(6-77 protein
(Ser-Il-872 protein
Gcp/Il-8 Protein I protein
Il8/Nap1 Form Iii protein
Lymphocyte-Derived Neutrophil-Activating Factor protein
Lynap protein
Mdncf-C protein
Neutrophil-Activating Factor protein
Naf - Il-8(7-77 protein
Gcp/Il-8 Protein V protein
Il8/Nap1 Form Iv - Il-8(8-77 protein
Gcp/Il-8 Protein Vi protein
Il8/Nap1 Form V - Il-8(9-77 protein
Gcp/Il-8 Protein Iii protein
Il8/Nap1 Form Vi protein
CXCL8 protein
IL8 protein

Information sourced from Uniprot.org

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