| Short Description : | Recombinant-Human IL-5 receptor alpha (CD125)-protein was developed from hek293. For use in research applications. |
| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Immunoreactivity: | Recombinant Human IL-5 receptor alpha (CD125) Activity was determined by its binding ability in a functional ELISA. Immobilized recombinant mouse IL-5 at 5 Mu g/ml can bind biotinylated human IL5Ra with a linear range of 30-4000 ng/mL. NA |
| Gene Symbol: | IL5RA |
| Gene ID: | 3568 |
| Uniprot ID: | IL5RA_HUMAN |
| Immunogen: | Optimized DNA sequence encoding extracellular domain of Human IL-5 receptor alpha including a C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region: | ECD |
| Tissue Specificity | Expressed on eosinophils and basophils. |
| Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCdw125Cd Antigen Cd125 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-5 Receptor Subunit Alpha proteinIl-5 Receptor Subunit Alpha proteinIl-5r Subunit Alpha proteinIl-5r-Alpha proteinIl-5ra proteinCdw125 proteinCd Antigen Cd125 proteinIL5RA proteinIL5R protein |
Information sourced from Uniprot.org
