• Biotinylated Human IL-5 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human IL-5 R alpha is greater than 95% as determined by SEC-HPLC.
  • Immobilized Human IL-5, His Tag at 0. 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human IL-5 R alpha, His Tag with the EC50 of 0. 12 Mu g/ml determined by ELISA.

Human IL-5 R alpha/CD125 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001617)

SKU:
STJP001617

£597.50 - £1,839.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-5 R alpha/CD125-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: IL5RA
Gene ID: 3568
Uniprot ID: IL5RA_HUMAN
Immunogen Region: Asp21-Glu335
Immunogen: DNA sequence encoding Human IL-5 R alpha/CD125 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
Protein Name Interleukin-5 Receptor Subunit Alpha
Il-5 Receptor Subunit Alpha
Il-5r Subunit Alpha
Il-5r-Alpha
Il-5ra
Cdw125
Cd Antigen Cd125
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-5 Receptor Subunit Alpha protein
Il-5 Receptor Subunit Alpha protein
Il-5r Subunit Alpha protein
Il-5r-Alpha protein
Il-5ra protein
Cdw125 protein
Cd Antigen Cd125 protein
IL5RA protein
IL5R protein

Information sourced from Uniprot.org

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