| Host: |
E.coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
CSF2RB |
| Gene ID: |
1439 |
| Uniprot ID: |
IL3RB_HUMAN |
| Immunogen Region: |
Trp17-Trp443 |
| Immunogen: |
Recombinant Human IL-3R Beta/CSF2RB/CD131 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Trp17-Trp443 ) of Human IL-3R Beta/CSF2RB/CD131 (Accession #NP_000386.1 fused with a His tag at the C-term |
| Immunogen Sequence: |
AELRCMCIKTTSGIHPKNIQ SLEVIGKGTHCNQVEVIATL KDGRKICLDPDAPRIKKIVQ KKLAGDESAD |
| Post Translational Modifications | May be phosphorylated by LYN. |
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Cytokine Receptor Common Subunit BetaCdw131Gm-Csf/Il-3/Il-5 Receptor Common Beta SubunitCd Antigen Cd131 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-5683826Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cytokine Receptor Common Subunit Beta proteinCdw131 proteinGm-Csf/Il-3/Il-5 Receptor Common Beta Subunit proteinCd Antigen Cd131 proteinCSF2RB proteinIL3RB proteinIL5RB protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
