Human IL-3R Beta/CSF2RB/CD131 protein (Recombinant) (No tag) (STJP002966)

SKU:
STJP002966

Current Stock:
Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/Mu g of the protein by LAL method.
Gene Symbol: CSF2RB
Gene ID: 1439
Uniprot ID: IL3RB_HUMAN
Immunogen Region: Trp17-Trp443
Immunogen: Recombinant Human IL-3R Beta/CSF2RB/CD131 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Trp17-Trp443 ) of Human IL-3R Beta/CSF2RB/CD131 (Accession #NP_000386.1 fused with a His tag at the C-term
Immunogen Sequence: AELRCMCIKTTSGIHPKNIQ SLEVIGKGTHCNQVEVIATL KDGRKICLDPDAPRIKKIVQ KKLAGDESAD
Post Translational Modifications May be phosphorylated by LYN.
Function Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway.
Protein Name Cytokine Receptor Common Subunit Beta
Cdw131
Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit
Cd Antigen Cd131
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-5683826
Reactome: R-HSA-5688849
Reactome: R-HSA-5688890
Reactome: R-HSA-912526
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cytokine Receptor Common Subunit Beta protein
Cdw131 protein
Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit protein
Cd Antigen Cd131 protein
CSF2RB protein
IL3RB protein
IL5RB protein

Information sourced from Uniprot.org

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