Human IL-37/IL-1F7 protein (Recombinant) (No-Tag) (STJP002909)

SKU:
STJP002909

£148.50 - £493.50
Current Stock:
Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: IL37
Gene ID: 27178
Uniprot ID: IL37_HUMAN
Immunogen Region: Lys27-Asp192
Immunogen: Recombinant Human IL-37/IL-1F7 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Lys27-Asp192) of human Interleukin-37/IL-37 (Accession #Q9NZH6-2) fused with No tag.
Immunogen Sequence: NPAAEAEFNILLATDSYKVT HYKQYPPNTSKVYSYFECRE KKTENSKLRKVKYEETVFYG LQYILNKYLKGKVVTKEKIQ EAKDVYKEHFQDDVFNEKGW NYILEKYDGHLPIEIKAVPE GFVIPRGNVLFTVENTDPEC YWLTNWIETILVQSWYPITV ATNSREQKKILAKYLLETSG NLDGLEYKLHDFGYRGVSSQ ETAGIGASAHLVNFKGTDTV AGLALIKKYYGTKDPVPGY
Tissue Specificity In general, low constitutive expression, if any, in healthy tissues.high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Post Translational Modifications Proteolytically converted to the mature form by CASP1.
Function Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Protein Name Interleukin-37
Il-37
Fil1 Zeta
Il-1x
Interleukin-1 Family Member 7
Il-1f7
Interleukin-1 Homolog 4
Il-1h
Il-1h4
Interleukin-1 Zeta
Il-1 Zeta
Interleukin-1-Related Protein
Il-1rp1
Database Links Reactome: R-HSA-9008059
Reactome: R-HSA-9012546
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Secreted
Stimulation With Il1b Leads To Colocalization With Smad3 Mostly In Perinuclear Regions
Only The Casp1-Cleaved Mature Form Translocates Into The Nucleus Upon Lps Stimulation
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names Interleukin-37 protein
Il-37 protein
Fil1 Zeta protein
Il-1x protein
Interleukin-1 Family Member 7 protein
Il-1f7 protein
Interleukin-1 Homolog 4 protein
Il-1h protein
Il-1h4 protein
Interleukin-1 Zeta protein
Il-1 Zeta protein
Interleukin-1-Related Protein protein
Il-1rp1 protein
IL37 protein
FIL1Z protein
IL1F7 protein
IL1H4 protein
IL1RP1 protein

Information sourced from Uniprot.org

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