Human IL-36Ra/IL36RN protein (Recombinant) (His-Tag) (STJP018914)

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STJP018914
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL-36Ra/IL36RN-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) 10% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: IL36RN
Gene ID: 26525
Uniprot ID: I36RA_HUMAN
Immunogen Region: 1-155aa
Accession Number: NP_036407
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD
Tissue Specificity Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Protein Name Interleukin-36 Receptor Antagonist Protein
Il-36ra
Fil1 Delta
Il-1-Related Protein 3
Il-1rp3
Interleukin-1 Hy1
Il-1hy1
Interleukin-1 Delta
Il-1 Delta
Interleukin-1 Family Member 5
Il-1f5
Interleukin-1 Receptor Antagonist Homolog 1
Il-1ra Homolog 1
Interleukin-1-Like Protein 1
Il-1l1
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names Interleukin-36 Receptor Antagonist Protein protein
Il-36ra protein
Fil1 Delta protein
Il-1-Related Protein 3 protein
Il-1rp3 protein
Interleukin-1 Hy1 protein
Il-1hy1 protein
Interleukin-1 Delta protein
Il-1 Delta protein
Interleukin-1 Family Member 5 protein
Il-1f5 protein
Interleukin-1 Receptor Antagonist Homolog 1 protein
Il-1ra Homolog 1 protein
Interleukin-1-Like Protein 1 protein
Il-1l1 protein
IL36RN protein
FIL1D protein
IL1F5 protein
IL1HY1 protein
IL1L1 protein
IL1RP3 protein
UNQ1896 protein
PRO4342 protein

Information sourced from Uniprot.org

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