Name: Human IL-36R/IL-1Rrp2/IL1RL2 protein (Recombinant) (C-His) (STJP001427)
SKU: STJP001427
Availability: InStock

Human IL-36R/IL-1Rrp2/IL1RL2 protein (Recombinant) (C-His) (STJP001427)

SKU:

STJP001427

£106.50 - £325.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g

Gene Symbol:	IL1RL2
Gene ID:	8808
Uniprot ID:	ILRL2_HUMAN
Immunogen:	Recombinant Human IL-36R/IL-1Rrp2/IL1RL2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp20-Arg335) of human IL-1 Rrp2/IL-1 R6 (Accession #NP_003845.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	DGCKDIFMKNEILSASQPFA FNCTFPPITSGEVSVTWYKN SSKIPVSKIIQSRIHQDETW ILFLPMEWGDSGVYQCVIKG RDSCHRIHVNLTVFEKHWCD TSIGGLPNLSDEYKQILHLG KDDSLTCHLHFPKSCVLGPI KWYKDCNEIKGERFTVLETR LLVSNVSAEDRGNYACQAIL THSGKQYEVLNGITVSITER AGYGGSVPKIIYPKNHSIEV QLGTTLIVDCNVTDTKDNT

Function	Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response.it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Protein Name	Interleukin-1 Receptor-Like 2 Il-36 Receptor Il-36r Interleukin-1 Receptor-Related Protein 2 Il-1rrp2 Il1r-Rp2
Database Links	Reactome: R-HSA-9007892 Reactome: R-HSA-9014826
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Interleukin-1 Receptor-Like 2 protein Il-36 Receptor protein Il-36r protein Interleukin-1 Receptor-Related Protein 2 protein Il-1rrp2 protein Il1r-Rp2 protein IL1RL2 protein IL1RRP2 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP000805	Human IL-36Ra/IL-1F5 protein (Recombinant) (C-His) (STJP000805)	E. coli
STJP002953	Human IL-12/IL-12A&IL-12B protein (Recombinant) (C-His＆C-Flag) (STJP002953)	HEK293 cells
STJP000802	Human IL-36 alpha/IL-1F6 protein (Recombinant) (C-His) (STJP000802)	E. coli
STJP000794	Human IL-36 beta/IL-1F8 protein (Recombinant) (C-His) (STJP000794)	E. coli
STJP002998	Human IL-25/IL-17E protein (Recombinant) (C-hFc&His) (STJP002998)	HEK293 cells

Human IL-36R/IL-1Rrp2/IL1RL2 protein (Recombinant) (C-His) (STJP001427)