Human IL-3 receptor (CD123) protein (Recombinant) (STJP000494)

SKU:
STJP000494
£222.50 - £4,784.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL-3 receptor (CD123)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Immunoreactivity: Recombinant Human IL-3 receptor alpha activity was measured using Immobilized human IL3 at 20 Mu g/ml ability to bind biotinylated human IL3RA with a linear ranger of 0.32-1.6 Mu g/ml NA
Gene Symbol: IL3RA
Gene ID: 3563
Uniprot ID: IL3RA_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding Human extracellular domain of human IL-3 receptor alpha chain including a C-terminal His tag was expressed in HEK293 cells. NA
Post Translational Modifications Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome.
Function Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name Interleukin-3 Receptor Subunit Alpha
Il-3 Receptor Subunit Alpha
Il-3r Subunit Alpha
Il-3r-Alpha
Il-3ra
Cd Antigen Cd123
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-3 Receptor Subunit Alpha protein
Il-3 Receptor Subunit Alpha protein
Il-3r Subunit Alpha protein
Il-3r-Alpha protein
Il-3ra protein
Cd Antigen Cd123 protein
IL3RA protein
IL3R protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP000897 Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897) HEK293 cells
STJP001733 Human IL-3 R alpha/CD123 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001733) HEK293
STJP000392 Human IL-6 Receptor (IL-6R) protein (Recombinant) (STJP000392) HEK293
STJP000609 Human IL-11 receptor alpha protein (Recombinant) (STJP000609) HEK293
STJP000455 Human IL-7 receptor (CD127) protein (Recombinant) (STJP000455) HEK293
STJP001774 Human IL-18 receptor 1 protein (Recombinant) (STJP001774)
STJP000542 Human IL-12 receptor beta 1 protein (Recombinant) (STJP000542) HEK293
STJP000598 Human IL-10 receptor beta (IL10RB) protein (Recombinant) (STJP000598) HEK293
!