Biotinylated Human IL-3 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human IL-3 R alpha/CD123 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001733)

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STJP001733
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Short Description :Recombinant-Human IL-3 R alpha/CD123-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:IL3RA
Gene ID:3563
Uniprot ID:IL3RA_HUMAN
Immunogen:DNA sequence encoding Human IL-3 R alpha/CD123 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Thr19-Arg305
Function Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name Interleukin-3 Receptor Subunit Alpha
Il-3 Receptor Subunit Alpha
Il-3r Subunit Alpha
Il-3r-Alpha
Il-3ra
Cd Antigen Cd123
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-3 Receptor Subunit Alpha protein
Il-3 Receptor Subunit Alpha protein
Il-3r Subunit Alpha protein
Il-3r-Alpha protein
Il-3ra protein
Cd Antigen Cd123 protein
IL3RA protein
IL3R protein

Information sourced from Uniprot.org

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