| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human IL-3 R alpha/CD123-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | IL3RA |
| Gene ID: | 3563 |
| Uniprot ID: | IL3RA_HUMAN |
| Immunogen Region: | Thr19-Arg305 |
| Immunogen: | DNA sequence encoding Human IL-3 R alpha/CD123 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. |
| Protein Name | Interleukin-3 Receptor Subunit Alpha Il-3 Receptor Subunit Alpha Il-3r Subunit Alpha Il-3r-Alpha Il-3ra Cd Antigen Cd123 |
| Database Links | Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-3 Receptor Subunit Alpha protein Il-3 Receptor Subunit Alpha protein Il-3r Subunit Alpha protein Il-3r-Alpha protein Il-3ra protein Cd Antigen Cd123 protein IL3RA protein IL3R protein |
Information sourced from Uniprot.org