• Biotinylated Human IL-3 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human IL-3 R alpha is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-IL-3 R alpha Antibody, hFc Tag at 0. 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human IL-3 R alpha, His Tag with the EC50 of 9. 9ng/ml determined by ELISA.

Human IL-3 R alpha/CD123 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001733)

SKU:
STJP001733

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-3 R alpha/CD123-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: IL3RA
Gene ID: 3563
Uniprot ID: IL3RA_HUMAN
Immunogen Region: Thr19-Arg305
Immunogen: DNA sequence encoding Human IL-3 R alpha/CD123 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name Interleukin-3 Receptor Subunit Alpha
Il-3 Receptor Subunit Alpha
Il-3r Subunit Alpha
Il-3r-Alpha
Il-3ra
Cd Antigen Cd123
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-3 Receptor Subunit Alpha protein
Il-3 Receptor Subunit Alpha protein
Il-3r Subunit Alpha protein
Il-3r-Alpha protein
Il-3ra protein
Cd Antigen Cd123 protein
IL3RA protein
IL3R protein

Information sourced from Uniprot.org

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