| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human IL-21R (CD360)-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised 0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: | Measured by its ability to inhibit IL21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. NA |
| Gene Symbol: | IL21R |
| Gene ID: | 50615 |
| Uniprot ID: | IL21R_HUMAN |
| Immunogen Region: | ECD |
| Immunogen: | Optimized DNA sequence encoding extracellular domain of human IL-21R receptor including a C terminal His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen. |
| Post Translational Modifications | C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. |
| Function | This is a receptor for interleukin-21. |
| Protein Name | Interleukin-21 ReceptorIl-21 ReceptorIl-21rNovel Interleukin ReceptorCd Antigen Cd360 |
| Database Links | Reactome: R-HSA-9020958 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-21 Receptor proteinIl-21 Receptor proteinIl-21r proteinNovel Interleukin Receptor proteinCd Antigen Cd360 proteinIL21R proteinNILR proteinUNQ3121 proteinPRO10273 protein |
Information sourced from Uniprot.org