| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1RN at 10 Mu g/mL (100 Mu L/well) can bind Recombinant Human IL1R2 with a linear range of 0.4-1.8 Mu g/mL. |
| Gene Symbol: | IL1RN |
| Gene ID: | 3557 |
| Uniprot ID: | IL1RA_HUMAN |
| Immunogen Region: | Arg26-Glu177 |
| Immunogen: | Recombinant Human IL-1RN Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg26-Glu177) of human IL-1RN (Accession #NP_776214.1) fused with an initial Met at the N-terminus and a 6×His tag at the C-term |
| Immunogen Sequence: | RPSGRKSSKMQAFRIWDVNQ KTFYLRNNQLVAGYLQGPNV NLEEKIDVVPIEPHALFLGI HGGKMCLSCVKSGDETRLQL EAVNITDLSENRKQDKRFAF IRSDSGPTTSFESAACPGWF LCTAMEADQPVSLTNMPDEG VMVTKFYFQEDE |
| Tissue Specificity | The intracellular form of IL1RN is predominantly expressed in epithelial cells. |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Protein Name | Interleukin-1 Receptor Antagonist ProteinIl-1rnIl-1raIrapIcil-1raIl1 InhibitorAnakinra |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 4: Cytoplasm |
| Alternative Protein Names | Interleukin-1 Receptor Antagonist Protein proteinIl-1rn proteinIl-1ra proteinIrap proteinIcil-1ra proteinIl1 Inhibitor proteinAnakinra proteinIL1RN proteinIL1F3 proteinIL1RA protein |
Information sourced from Uniprot.org