Human IL-1Ra/IL1RN protein (Recombinant) (No-Tag) (STJP019429)

Name: Human IL-1Ra/IL1RN protein (Recombinant) (No-Tag) (STJP019429)
SKU: STJP019429
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP019429

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Recombinant-Human IL-1Ra/IL1RN-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications	SDS-PAGE/Bioactivity
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid In Phosphate-Buffered Saline (pH7.4)
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity	The activity is determined by the IFN-g ELISA in a using NK-92 human natural killer cells. The ED50 range ≤10 ng/ml.

Gene Symbol	IL1RN
Gene ID	3557
Uniprot ID	IL1RA_HUMAN
Accession Number	NP_776214
Immunogen	Human
Immunogen Region	26-177aa
Immunogen Sequence	MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Tissue Specificity	The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Function	Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Protein Name	Interleukin-1 Receptor Antagonist Protein Il-1rn Il-1ra Irap Icil-1ra Il1 Inhibitor Anakinra
Database Links	Reactome: R-HSA-6783783 Reactome: R-HSA-9020702
Cellular Localisation	Isoform 1: Secreted Isoform 2: Cytoplasm Isoform 3: Cytoplasm Isoform 4: Cytoplasm
Alternative Protein Names	Interleukin-1 Receptor Antagonist Protein protein Il-1rn protein Il-1ra protein Irap protein Icil-1ra protein Il1 Inhibitor protein Anakinra protein IL1RN protein IL1F3 protein IL1RA protein

Information sourced from Uniprot.org