Human IL-16 protein (Recombinant) (No-Tag) (STJP019104)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IL-16-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL16 |
| Gene ID | 3603 |
| Uniprot ID | IL16_HUMAN |
| Accession Number | NP_004504 |
| Immunogen | Human |
| Immunogen Region | 502-631aa |
| Immunogen Sequence | MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS |
Additional Info
| Tissue Specificity | Isoform 3: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation. |
| Post Translational Modifications | Isoform 3: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16. |
| Function | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1: May act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Protein Name | Pro-Interleukin-16 Cleaved Into - Interleukin-16Il-16Lymphocyte Chemoattractant FactorLcf |
| Database Links | Reactome: R-HSA-449836 |
| Cellular Localisation | Interleukin-16: SecretedIsoform 1: CytoplasmIsoform 3: CytoplasmNucleus |
| Alternative Protein Names | Pro-Interleukin-16 Cleaved Into - Interleukin-16 proteinIl-16 proteinLymphocyte Chemoattractant Factor proteinLcf proteinIL16 protein |
Information sourced from Uniprot.org